![]() ![]() The resulting keratin-PEG hydrogels showed highly tunable mechanical properties of up to 45 kPa in compressive modulus, and long-term stability in buffer solutions and cell culture media. Here, we report the preparation of photocrosslinkable keratin-polyethylene glycol (PEG) hydrogels via the thiol-norbornene "click" reaction, which can be formed within one minute upon irradiation of visible light. However, the fabrication of keratin-based scaffolds typically relies on limited crosslinking mechanisms, such as via physical interactions or disulfide bond formation, which are time-consuming and result in relatively poor mechanical strength and stability. Keratins extracted from human hair have emerged as a promising biomaterial for various biomedical applications, partly due to their wide availability, low cost, minimal immune response, and the potential to engineer autologous tissue constructs. 10 Nanotechnology Center King Abdulaziz University Jeddah 21569 Saudi Arabia.of Bioindustrial Technologies College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong Gwangjin-gu Seoul 143-701 Republic of Korea. of Chemical Engineering Northeastern University Boston MA 02115. 7 Wyss Institute for Biologically Inspired Engineering, Harvard University Boston MA 02115.of Chemistry and Key Laboratory of Biomedical Polymers, Ministry of Education Wuhan University Wuhan 430072 China. 5 Research Center for Analysis and Measurement Hebei Normal University Shijiazhuang 050024 Hebei China.4 School of Materials Science and Engineering Nanyang Technological University, N4.1, 50 Nanyang Avenue Singapore 639798 Singapore.3 College of Textiles, Donghua University Shanghai 201620 China.2 Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139. ![]() of Medicine, Biomaterials Innovation Research Center Brigham and Women's Hospital, Harvard Medical School Cambridge MA 02139. ![]()
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